Medications to treat nocturia
Different medicinal options exist to alleviate and even treat nocturia. These may be used alone or combined with some of the behavioral modifications listed above, which has been proven to be more effective. A word of caution about medications: Used alone, studies have confirmed that the medication works only as long as it is taken. Once off the medication, relapses are quite common.

Anticholinergic medications (Vesicare, Ditropan, Enablex) are prescription medications that are effective for treating nocturia associated with bladder over activity. The main side effects with anticholinergic medications are dry mouth, dizziness, and blurred vision.

Another drug, Mybetriq, is helpful as it relaxes the bladder at night and allows the bladder to hold more urine.

If this first line drug therapy is considered ineffective, one or more of the following may be prescribed.

Desmopressin or  vasopressin, is a nasal spray that works on the kidneys to reduce urine production at night. Noctiva is taken daily, approximately 30 minutes before going to bed. The U.S. Food and Drug Administration today approved Noctiva (desmopressin acetate) nasal spray for adults who awaken at least two times per night to urinate. Noctiva is the first FDA-approved treatment for this condition.